Integrative single-cell and exosomal multi-omics uncovers SCNN1A and EFNA1 as non-invasive biomarkers and drivers of ovarian cancer metastasis
By coupling single-cell, bulk tissue, and exosomal transcriptomics, we elucidated the key molecular drivers of OV metastasis and established SCNN1A and EFNA1 as promising non-invasive biomarkers. This multi-omics framework provides an effective strategy for early detection and a better understanding of metastatic progression in OV.
Authors
- Shaohua Chen (ORCID: https://orcid.org/0000-0003-3544-3138)
- Liping Tang (ORCID: https://orcid.org/0000-0002-9757-7548)
- Dong Pang (ORCID: https://orcid.org/0000-0002-0448-9128)
- Chengbang Wang
- Jiali Lin
- Jiangchun Wu
- Junqi Cui
Institutions
- Guangxi Medical University (CN)
- Second Military Medical University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Ninth People's Hospital (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1630794
- Citations
- 2
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.40