Programmed cell death signatures-driven microglial transformation in Alzheimer’s disease: single-cell transcriptomics and functional validation
This study developed a robust PCDS model for AD prediction and identified S100A4 as a potential therapeutic target. The findings highlight the importance of PCD pathways in AD pathogenesis and provide new insights for early diagnosis and intervention.
Authors
- Mi-Mi Li
- Shu-Juan Wu
- Yingxia Yang
- Wenying Huang (ORCID: https://orcid.org/0000-0001-8787-9991)
- Yingying Xu (ORCID: https://orcid.org/0000-0001-8224-2342)
- Ya-Li Huang (ORCID: https://orcid.org/0000-0002-0678-231X)
- Lichao Ye (ORCID: https://orcid.org/0000-0001-7706-5644)
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1610717
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53