Genetic variants and clinical determinants affecting the response to 5-Fluorouracil-based treatment in Chilean patients with advanced colorectal cancer
This study provides a foundation for developing pharmacogenetic-based predictive models for adverse reactions associated with 5-FU, including neuropathy, mucositis, and hematological and skin toxicities. Future research may refine these models to enable personalized dose adjustments, improving chemotherapy safety in Chilean colorectal patients.
Authors
- Aurora Ortiz Nuñez
- Bettina Müller (ORCID: https://orcid.org/0000-0002-8589-5725)
- María A. Lavanderos (ORCID: https://orcid.org/0000-0001-6167-0508)
- Nelson Varela (ORCID: https://orcid.org/0000-0002-5229-3007)
- Luis A. Quiñones (ORCID: https://orcid.org/0000-0002-7967-5320)
- Leslie C. Cerpa (ORCID: https://orcid.org/0000-0002-9525-389X)
- Paula Escalante
- Alicia Colombo (ORCID: https://orcid.org/0000-0002-2690-146X)
- Olga Barajas
- Juan Pablo Cayún (ORCID: https://orcid.org/0000-0003-3781-7092)
- Gerardo Donoso
- Cristina Quiroz
- Carolina Gutiérrez-Cáceres (ORCID: https://orcid.org/0009-0002-4190-2927)
- Christopher Sandoval
- Claudio Alarcón-Concha
- Guillermo Kaempfe
- Diego Moreno-Tapia
Institutions
- Fundación Chile (CL)
- Universidad de Costa Rica (CR)
- Chinese Academy of Science South America Center for Astronomy (CL)
- Business University of Costa Rica (CR)
- Instituto Profesional Escuela De Contadores Auditores De Santiago (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- Facultad Latinoamericana de Ciencias Sociales (CL)
- Universidad Libre de Costa Rica (CR)
- Instituto Nacional del Cáncer (CL)
- University of Bío-Bío (CL)
- Chilean Air Force (CL)
- University of Chile (CL)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fonc.2025.1589724
- Citations
- 1
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Universidad de Chile
- Agencia Nacional de Investigación y Desarrollo
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias