Case Report: Two instances of lung metastasis in low-grade endometrial stromal sarcoma.

Low-grade endometrial stromal sarcoma (LESS) lung metastasis is common in middle-aged and elderly women. While the overall survival rate is good, patients with long-term recurrence or metastasis, especially those with localized or non-metastatic tumors, face a high risk of disease progression. Currently, there is no standardized chemotherapy regimen for this condition. We report two cases of LGESS pulmonary metastasis, analyzing clinical features, histological morphology, immunohistochemistry, and differential diagnosis to enhance understanding of this condition. Without a medical history, it is easy to misdiagnose, particularly in cases of LGESS, where atypical symptoms can lead to misdiagnosis. Regular follow-up, prompt diagnosis, and treatment are crucial for improving prognosis and survival.