Single-cell transcriptomic profiling reveals the heterogeneity of epithelial cells in lung adenocarcinoma lymph node metastasis and develops a prognostic signature.
This research provides insights into the evolutionary complexity and heterogeneity of malignant epithelial populations in lymph node metastatic sites of LUAD. It also presents a scoring system based on prognostic indicators, which serves as a reliable tool for forecasting patient survival outcomes. Moreover, the discovery of SELENBP1 as a candidate tumor suppressor emphasizes its importance in guiding both clinical risk categorization and the design of personalized treatment strategies for individuals classified as high-risk LUAD cases.
Authors
- Ying Shi (ORCID: https://orcid.org/0000-0003-4439-0592)
- Mengli Xue (ORCID: https://orcid.org/0000-0002-3324-3303)
- Xin Li (ORCID: https://orcid.org/0000-0001-8328-4894)
- Han Zhang (ORCID: https://orcid.org/0000-0001-8498-3451)
- Hui Yuan (ORCID: https://orcid.org/0000-0001-9627-1654)
- Lin Tan (ORCID: https://orcid.org/0000-0001-5096-0497)
- Yun Ding (ORCID: https://orcid.org/0000-0002-7519-3623)
- Daqiang Sun (ORCID: https://orcid.org/0009-0001-6315-0001)
- Jingxian Wang (ORCID: https://orcid.org/0000-0002-9484-6570)
- Qiuqiao Mu
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Fujian Provincial Hospital (CN)
- Tianjin Chest Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1637625
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00