Single-cell and spatial atlas of glioblastoma heterogeneity: characterizing the PCLAF+ subtype and YEATS4’s oncogenic role
Our study systematically elucidated the malignant characteristics of the C2 <i>PCLAF</i>+ subtype and its molecular mechanisms driving GBM progression. This subtype promoted therapeutic resistance through unique metabolic reprogramming, MDK-LRP1-mediated microenvironmental interactions, and immunosuppressive properties. <i>YEATS4</i> knockdown effectively suppressed malignant tumor behaviors, highlighting its therapeutic potential. These findings provided novel targeted intervention strategies to address GBM heterogeneity and treatment resistance, offering promising avenues for overcoming current therapeutic limitations.
Authors
- Dongming Yan (ORCID: https://orcid.org/0000-0001-6036-2298)
- Yilong Fu
- Henan Jiao
- Liangyu Wang (ORCID: https://orcid.org/0009-0000-5212-7423)
- Siqi Ma (ORCID: https://orcid.org/0000-0002-3796-2911)
- Zi Ye (ORCID: https://orcid.org/0000-0002-4980-358X)
- Di Chen (ORCID: https://orcid.org/0000-0002-9854-8685)
- Dun Liu (ORCID: https://orcid.org/0000-0003-1266-8801)
- Shaowei Zheng
- Xueyuan Li (ORCID: https://orcid.org/0000-0002-0138-2296)
- Yuwei Sun (ORCID: https://orcid.org/0009-0004-1580-0462)
- Xuqiang Zhu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1614549
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81