Double-Strand Breaks Induce Nuclear-Cytosolic Shuttling of Polymorphic DNA Mismatch Repair Protein MutS Homolog 3 and Binding to NEMO/IKKγ in Colon Cancer Cells
These findings suggest that inflammatory proteins are important for Δ27bpMSH3 translocation to the cytosol but also for stabilizing MSH3 when separated from nuclear MSH2.
Authors
- Stephanie Tseng-Rogenski
- John M. Carethers (ORCID: https://orcid.org/0000-0003-2623-7332)
- Minoru Koi (ORCID: https://orcid.org/0000-0002-1195-071X)
Institutions
- University of Michigan (US)
- University of California San Diego (US)
- Human Longevity (United States) (US)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100756
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- University of Michigan
- Division of Cancer Prevention, National Cancer Institute
- U.S. Public Health Service