From gut to joint: the protective impact of Eubacterium rectale on rheumatoid arthritis
The study demonstrates that <i>E. rectale</i> has a protective effect on RA. <i>E. rectale</i> significantly attenuates joint inflammation in mouse models by may regulating the expression level of butyrate, ameliorating the Treg and Tfr/Tfh immune imbalance status, and re-establishing the immune tolerance. These findings serve as valuable references for future studies on the pathogenesis of RA and the development of new therapeutic approaches.
Authors
- Baochen Li (ORCID: https://orcid.org/0000-0001-5593-9697)
- Ruihe Wu
- Caihong Wang (ORCID: https://orcid.org/0000-0002-6808-3709)
- Chong Gao (ORCID: https://orcid.org/0000-0001-7639-0808)
- Xiaoyang Liu (ORCID: https://orcid.org/0000-0002-1202-6764)
- Yuxin Fan (ORCID: https://orcid.org/0000-0003-1561-1472)
- Kaili Qin (ORCID: https://orcid.org/0000-0001-9575-9279)
- Xiaofeng Li (ORCID: https://orcid.org/0009-0007-0076-8094)
Institutions
- Brigham and Women's Hospital (US)
- Shanxi Medical University (CN)
- Shanxi Taiyuan Jinkang Rheumatism Hospital (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1607804
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China