Insights into intestinal barrier disruption during long-term gut Chlamydia colonization in mice: a single-cell transcriptomic approach
These findings highlight how <i>Chlamydia</i> may exploit host cell pathways to establish long-term colonization in the gut. The impairment of epithelial barrier function and altered cellular crosstalk provide novel insights into its persistence strategies. Understanding these mechanisms could inform future therapeutic approaches targeting chronic <i>Chlamydia</i> infections.
Authors
- Zhenzhen Wan
- Qí Zhāng (ORCID: https://orcid.org/0000-0001-6300-6491)
- Yicun Jiang
- Zengzi Zhou (ORCID: https://orcid.org/0000-0001-9840-0464)
- Sheng Xie (ORCID: https://orcid.org/0000-0003-0754-4134)
- Chuqiang Shu (ORCID: https://orcid.org/0000-0002-7431-4235)
- Tianyuan Zhang (ORCID: https://orcid.org/0000-0001-8968-563X)
- Xin Sun (ORCID: https://orcid.org/0000-0002-1017-3189)
- Youyou Huang
- Qi Tian (ORCID: https://orcid.org/0000-0002-9424-3657)
- Jiao Wan
- Luying Wang (ORCID: https://orcid.org/0000-0003-2820-1341)
Institutions
- Central South University (CN)
- Shanghai Jiao Tong University (CN)
- Institut Pasteur of Shanghai (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
- Institute of Natural Science (KP)
- Xiangya Hospital Central South University (CN)
- Hunan Provincial Maternal and Child Health Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fcimb.2025.1614009
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00