Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot study

Introduction: Pathological scars, despite the achievements of modern medicine, are still a problem. Its prevalencecan reach up to 50% in emergency surgeries. These scars can lead to physical complications, includingimpaired mobility, altered sensation, and discoloration, and may even cause pain. In this study, we explore thepossibilities of using the combined drug of recombinant collagenase and lyase enzymes, and high molecularweight hyaluronic acid (HMWHA) pbserum HIGH in the treatment of pathological scars.Methods: patients of the main group received a course of intra-cicatricial injections of the drug, treatment resultswere assessed clinically, according to the Vancouver Scar Scale (VSS) and Observer Scar Assessment Scale (POSAS)scales, the results were compared morphologically with standard scars treatment methods (biopsies were takenbefore and after treatment).Results: Clinically, patients of the main group received a pronounced positive transformation of scar tissue in 6weeks, statistical processing of data confirms the reliability of changes, morphological studies prove the normotrophic nature of the changes in the scars (including comparison with the control group).Conclusions: Remedy of recombinant collagenase and lyase enzymes in combination with HMWHA pbserum HIGHin the form of the course of intra-cicatricial injections is a safe and effective method of treating pathological scars.