Solid Lipid Nanoparticles for Poorly Soluble Drugs: Formulation and Evaluation

Poor water solubility is still a big problem in medication development since it typically makes oral formulations less bioavailable and less effective at treating diseases. The goal of this project was to create and test solid lipid nanoparticles (SLNs) as a new way to deliver medications that don't dissolve well. Four SLN formulations were made and tested using a hot homogenization followed by ultrasonication method. The tests looked at the size of the particles, the polydispersity index (PDI), the zeta potential, the entrapment efficiency, the drug loading, and the in vitro drug release. The results showed that higher concentrations of surfactants and lipids made the particles smaller, trapped more drugs, and released them over a longer period of time. Formulation F4 had the best performance, with a particle size of 130 nm, an entrapment efficiency of 88%, and a drug release rate of 85% at 24 hours. Statistical analysis showed that there were big differences across the formulations (p < 0.05). Morphological and thermal examinations showed that the nanoparticles' structures were still strong. The results show that SLNs could be a good way to improve the solubility and bioavailability of hydrophobic medications, and they could even be developed into dosage forms that work in the clinic.