Bridging the gaps in detection of structural cardiotoxicity in stem cell-derived cardiomyocytes: promise of miR-133b, miR-184 and miR-208b-3p
The combination of intracellular and secreted miRNAs in hiPSC-CM might expand the tools for early identification of structural cardiotoxicity in preclinical drug discovery and provide a potential link to circulating miRNAs in patients with drug-induced cardiotoxicity.
Authors
- Annie Delaunois (ORCID: https://orcid.org/0000-0001-6345-7989)
- Maaike Alaerts (ORCID: https://orcid.org/0000-0002-1376-3635)
- Jean‐Pierre Valentin (ORCID: https://orcid.org/0000-0002-3599-9155)
- Vitalina Gryshkova (ORCID: https://orcid.org/0000-0001-6044-0479)
- Pieter‐Jan Guns (ORCID: https://orcid.org/0000-0002-8640-6620)
- Martina Cherubin
Institutions
- University of Antwerp (BE)
- Antwerp University Hospital (BE)
- UCB Pharma (Belgium) (BE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fphar.2025.1584734
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Horizon 2020 Framework Programme