A typical Presentation of Myasthenia Gravis: A Clinical Sequelae of Thymoma

Myasthenia gravis (MG) is an autoimmune disorder in which antibodies block the acetylcholine receptors in the post synaptic membrane causing skeletal muscle weakness. The weakness can be localized or diffuse. MG predominantly affects the bulbar muscles and 15% of the cases are confined to the ocular muscles. Although MG is classically recognized as a disorder of muscle function, non-motor manifestations, particularly altered somatic sensation, are overlooked and underreported. This under recognition has contributed to a limited awareness among clinicians regarding the wider range of MG presentations. MG is a disease that can manifest with both motor and sensory symptoms. We present the case of a male patient subsequently diagnosed with thymoma, who initially exhibited abnormal sensory perceptions prior to the onset of muscular weakness. The diagnosis of MG was only established following the development of motor impairment. This case underscores the need for heightened clinical suspicion regarding atypical presentations of MG. The underappreciation of sensory symptoms may delay diagnosis and contribute to increased patient morbidity.

Authors

Publication Details

Journal
Annals of Clinical and Medical Case Reports
Published
2025-01-01
DOI
https://doi.org/10.47829/acmcr.2025.141109
Primary Topic
Myasthenia Gravis and Thymoma
Type
article
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article

A typical Presentation of Myasthenia Gravis: A Clinical Sequelae of Thymoma

Akil Gafarbhai Parmar, A. Shahid, A. López Miranda, Mohd Rafiw Ahmed Mahen
Annals of Clinical and Medical Case Reports
Myasthenia Gravis and Thymoma
article

A typical Presentation of Myasthenia Gravis: A Clinical Sequelae of Thymoma

Akil Gafarbhai Parmar, A. Shahid, A. López Miranda, Mohd Rafiw Ahmed Mahen
article en

Abstract

Myasthenia gravis (MG) is an autoimmune disorder in which antibodies block the acetylcholine receptors in the post synaptic membrane causing skeletal muscle weakness. The weakness can be localized or diffuse. MG predominantly affects the bulbar muscles and 15% of the cases are confined to the ocular muscles. Although MG is classically recognized as a disorder of muscle function, non-motor manifestations, particularly altered somatic sensation, are overlooked and underreported. This under recognition has contributed to a limited awareness among clinicians regarding the wider range of MG presentations. MG is a disease that can manifest with both motor and sensory symptoms. We present the case of a male patient subsequently diagnosed with thymoma, who initially exhibited abnormal sensory perceptions prior to the onset of muscular weakness. The diagnosis of MG was only established following the development of motor impairment. This case underscores the need for heightened clinical suspicion regarding atypical presentations of MG. The underappreciation of sensory symptoms may delay diagnosis and contribute to increased patient morbidity.

Annals of Clinical and Medical Case ReportsVol. 14(11)
Openalex Percentile: Top 71%
Myasthenia Gravis and Thymoma
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A typical Presentation of Myasthenia Gravis: A Clinical Sequelae of Thymoma — Akil Gafarbhai Parmar, A. Shahid, et al. · Annals of Clinical and Medical Case Reports (2025) | TGRS Research Map | TGRS