Piperine protects against cerebral ischemic injury by regulating the Caspase-1-mediated pyroptosis pathway
Pip exerts neuroprotective effects by modulating the Caspase-1-mediated pyroptosis pathway, which inhibits neuronal damage in the pMCAO model. These findings highlight the therapeutic potential of Pip in mitigating cerebral ischemic injury.
Authors
- Xueyan Fu (ORCID: https://orcid.org/0000-0001-6766-9129)
- Siyu Xi
- Yiwei Zhang (ORCID: https://orcid.org/0000-0001-9007-8781)
- Bo Wang (ORCID: https://orcid.org/0000-0001-9092-3252)
- Juan Liu (ORCID: https://orcid.org/0000-0002-2434-3513)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-0470-772X)
- Jiayuan Lu
- Xufeng Dai (ORCID: https://orcid.org/0000-0003-4205-5774)
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fphar.2025.1601873
- Citations
- 2
- Primary Topic
- Piperaceae Chemical and Biological Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningxia Province