Chaihu Longgu Muli Decoction inhibits chronic stress-induced lung cancer epithelial-mesenchymal transition process by suppressing Rap1/ERK signal pathway
These findings suggest that Rap1/ERK-mediated EMT is a hallmark of chronic stress-associated lung cancer progression. CLM exerts its therapeutic effects by targeting this pathway, offering a novel strategy to mitigate stress-aggravated oncogenesis.
Authors
- Zhenzhen Guo (ORCID: https://orcid.org/0000-0002-3228-3741)
- Erping Xu (ORCID: https://orcid.org/0000-0001-7384-9839)
- Yucheng Li (ORCID: https://orcid.org/0000-0003-0944-5308)
- Zibo Li (ORCID: https://orcid.org/0000-0002-1063-0298)
- Bao-Ying Wang (ORCID: https://orcid.org/0000-0002-7824-4457)
- Ziyang Huang (ORCID: https://orcid.org/0000-0002-6496-5173)
- Zhiyi Wang (ORCID: https://orcid.org/0009-0008-1688-3342)
Institutions
- Nanyang Normal University (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-25
- DOI
- https://doi.org/10.3389/fphar.2025.1644315
- Citations
- 3
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Henan University of Chinese Medicine
- Henan University