Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes
This study reveals that PSNPs disrupt hepatocyte lipid and amino acid metabolism and identifies key genes using an integrated omics approach. It provides data for understanding MNP hazards and assessing health risks.
Authors
- Yuqing Song
- Tingting Wei (ORCID: https://orcid.org/0000-0002-7796-0902)
- Man Yang (ORCID: https://orcid.org/0000-0001-8432-5707)
- Rongzhang Hao (ORCID: https://orcid.org/0000-0002-1527-427X)
- Yuting Fang (ORCID: https://orcid.org/0000-0002-2819-7664)
- Yukang Zhang (ORCID: https://orcid.org/0009-0007-4547-5877)
- Yajie Wang (ORCID: https://orcid.org/0000-0003-3404-3319)
- Zhiwei Sun (ORCID: https://orcid.org/0000-0003-4470-9743)
- Yanbo Li (ORCID: https://orcid.org/0000-0001-5414-0736)
- Ji Wang (ORCID: https://orcid.org/0000-0001-9675-1455)
- Huraira Akhtar (ORCID: https://orcid.org/0000-0002-5228-3538)
Institutions
- Capital Medical University (CN)
- Beijing Ditan Hospital (CN)
Publication Details
- Journal
- Environmental Science Nano
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5en00161g
- Primary Topic
- biodegradable polymer synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University
- Natural Science Foundation of Beijing Municipality
- Beijing Municipal Health Commission
- Beijing Nova Program