Preparation And Evaluation of Nebivolol Microcapsule

Microencapsulation is an advanced technique used to protect, preserve, and deliver active materials in various industries like pharmaceuticals, cosmetics, fragrances, paints, coatings, detergents, food products, and agrochemicals. Polymeric materials are commonly used as microcapsule shells to provide effective barrier properties and achieve controlled release of the active ingredient inside. However, these capsules have some significant limitations. They can suffer from unwanted leaching, and the polymers typically used are not biodegradable. Additionally, the energy cost involved in manufacturing microcapsules is an important factor to consider when designing these systems and their production processes. The encapsulation techniques e.g., solvent evaporation phase separation normally involves water insoluble polymers as carrier which require large quantity of organic solvents for the solubilization. As a result, the process becomes vulnerable to safety hazards, toxicity and increases the cost of production making the techniques non reproducible, economically and ecologically at an industrial scale. These concerns demand a technique free from organic solvent. Thus, the objective of this study was to encapsulate Nebivolol with hydrophilic polymers such as sodium alginate, HPMC& methylcellulose. These polymeric dispersions form a homogenous film on drying and provide a controlled release of the drug from the polymer matrix. In the present investigation, Nebivolol loaded microspheres prepared by hydrophilic polymers such as sodium alginate, HPMC, and methylcellulose with an objective of developing mucoadhesive microspheres of Nebivolol by Ionotropic gelation method.