Transcriptomic Analysis of Taar5 Expression and Co-Expression Networks in the Cerebellum During Perinatal Development

<b>Background:</b> Dopamine participates in the cognitive cerebellar role and in cerebellum development. The trace amine-associated receptor (TAARs, TAAR1-TAAR9) system contributes to dopamine signaling tuning. So, the aim of the present study is the analysis of the TAARs' gene expression and functional associations in prenatal and neonatal mouse cerebellums. <b>Methods:</b> The transcriptomic data represented in the GEO repository was performed to identify Taars expression and co-expression patterns in embrionic and postnatal mouse cerebellum. <b>Results:</b> Open transcriptomic data analysis showed cerebellar expression of the <i>Taar5</i> gene mRNA both in prenatal and early postnatal samples. The identified <i>Taar5</i> expression was confirmed by RT-PCR in P5 mice. We identified the association between <i>Taar5</i> expression and the expression of proliferation-related genes in late prenatal E13.5 samples, which was replaced by co-expression with genes involved in metabolism in P5-6 samples. These associations are suggested to mirror the previously identified <i>Taar5</i> expression in Purkinje cells, which proliferate at the E13.5 and mature in the postnatal period. However, the analysis of TAAR5 co-expression with markers of different cell populations revealed the pronounced co-expression of TAAR5 in the P5-6 cerebellum with microglial markers, which is shifted to the association with astroglial markers in P10. <b>Conclusions:</b> The <i>Taar5</i> gene was found to be active in the cerebellum samples taken around birth, and its co-expression pattern differs in the embryo stage and the early days after birth. We suggest that the Taar5 receptor may be involved in cerebellum development; however, further research is necessary to elucidate its role in this process.