Revealing key regulatory factors in lung adenocarcinoma: the role of epigenetic regulation of autophagy-related genes from transcriptomics, scRNA-seq, and machine learning
In this study, we utilized bulk and single-cell transcriptomic data to uncover the potential molecular mechanisms of A-ERGs in lung cancer. We explored the characteristic distribution of these genes in the tumor immune microenvironment and identified two A-ERGs, KDM6B and KANSL1, as potential diagnostic biomarkers for lung adenocarcinoma (LUAD). Our findings offer novel strategies for targeted therapeutic interventions in LUAD.
Authors
- Lingyun Wei
- Yingying Shen
- Xianghui Kong (ORCID: https://orcid.org/0000-0001-5917-6770)
- Lu Lv (ORCID: https://orcid.org/0000-0001-5966-3464)
- Xianchang Zeng
- Xinliang Lu (ORCID: https://orcid.org/0000-0002-2115-1647)
- Jianli Wang
- Di Wu (ORCID: https://orcid.org/0000-0002-2176-2691)
- Zhijian Cai (ORCID: https://orcid.org/0009-0006-3742-8133)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Cancer Hospital (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fphar.2025.1542338
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Science and Technology Program of Zhejiang Province