The Effects of Irisin and Bevacizumab on Hyaline Cartilage Regeneration in Osteochondral Defects: An Experimental Study in Rats
To the best of our knowledge, this study is the first to investigate intra-articular IR in FTCDs. The IR and BEVA-IR groups, particularly the BEVA-IR group, demonstrated superior outcomes in all evaluations. These findings suggest that combining BEVA and IR has synergistic effects on cartilage healing in FTCDs.
Authors
- Özgür Bulmuş (ORCID: https://orcid.org/0000-0001-7736-402X)
- Gülay Turan (ORCID: https://orcid.org/0000-0002-3702-8811)
- Emrah Özcan (ORCID: https://orcid.org/0000-0002-6373-4744)
- Ahmet Emrah Açan (ORCID: https://orcid.org/0000-0001-7116-8773)
- Aslı Karakılıç (ORCID: https://orcid.org/0000-0001-7788-4949)
- Sevban Bayırlı (ORCID: https://orcid.org/0000-0001-5428-1109)
- Memduh Aydın (ORCID: https://orcid.org/0009-0006-6124-7842)
Institutions
- Balıkesir University (TR)
- University of Turku (FI)
- Turku University Hospital (FI)
- Istanbul Medipol University (TR)
Publication Details
- Journal
- Clinics in Orthopedic Surgery
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4055/cios24502
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Balikesir Üniversitesi