Lipid Nanocarrier Gel: Promising Novel Drug Delivery System

Background: Nanostructured lipid carriers (NLCs) are advanced colloidal drug delivery systems composed of a mixture of solid and liquid lipids.Compared to metallic or polymeric nanoparticles, NLCs are considered safer, non-toxic, and biocompatible, making them highly suitable for pharmaceutical applications.Objectives: This study aimed to provide an in-depth overview of NLCs, focusing on their composition, structural characteristics, methods of preparation, advantages, and recent advancements, particularly in the formulation of lipid nanocarrier-based gels.Methods: NLCs are formulated using various techniques, such as high-pressure homogenization, solvent evaporation, and microemulsion methods.These approaches, along with the use of appropriate solid and liquid lipids and surfactants, enable the customization of NLCs for specific therapeutic needs.The study reviewed recent literature to assess the performance and potential of NLCs in drug delivery.Results: NLCs exhibit improved stability, enhanced drug loading, controlled and sustained drug release, and increased permeability of poorly water-soluble drugs.These characteristics make them effective for targeted delivery in the treatment of chronic and complex conditions, such as cancer, infections, neurological disorders, diabetes, hypertension, and pain management.Additionally, their application in gel-based formulations supports long-term treatment of skin and wound-related disorders. Conclusion:Due to their biocompatibility, stability, and versatility, NLCs represent a promising platform for innovative drug delivery.However, comprehensive clinical evaluation of their long-term safety, toxicity, and bio-compatibility is essential.This review highlights the structure, classification, ingredients, formulation methods, and recent advancements in NLC technology, underlining their growing role in modern therapeutics.