Wound Healing Properties of Cyperus Papyrus Ethanolic Extract in Wister Albino Rats

Background: Cyperus papyrus has been used to treat various health problems, such as ulcers and inflammation.Its possible use to promote healing, especially in the case of wounds, is still a topic that lacks thorough research.Objectives: This study assessed the wound-healing effect of the ethanolic extract of C. papyrus in Wistar rats using an excision wound model. Methods:The ethanolic extract of C. papyrus was made into gels at concentrations of 5% and 10%.Excisional wounds were induced on the dorsal of Wistar rats, which were treated topically with the gels twice daily.The effects of the treatment were evaluated through macroscopic measurements of wound contraction daily, histopathological analysis, and regeneration assessment by day 14.Results: Wounds treated with C. papyrus gel at both concentrations of 5% and 10% showed increased rates of wound contraction when compared to the control group and the 10% formulation showed the most pronounced effect.Staining identifiable changes were noted that suggested enhanced epithelialization, advanced collagen maturation, inflammatory exocytosis within lower ranges of collagen deposition in the left interstitial tissue, and a decrease in the remaining inflammatory cells. Conclusion:Using a 10% gel of C. papyrus extract through a topical procedure may increase the rate of wound healing in rats.This is probably due to the anti-inflammatory and antioxidant effects of the extract.These results confirm its effectiveness for further development of herbal therapeutic medicines to promote wound healing.