Discovery of Diverse Seven-Membered Ring Vibsane Diterpenoids from <i>Viburnum awabuki</i> Utilizing a MassQL-Integrated Strategy and Their Antihepatoma Effect
Through a MassQL-integrated strategy, 26 vibsane diterpenoids (VibDs) were identified from <i>Viburnum awabuki</i>, including 15 new compounds (<b>1-15</b>) and 11 known analogues (<b>16-26</b>). Compound <b>1</b> possessed an unprecedented seven-membered ring scaffold, representing a new type of VibD. The hypothetical biosynthetic pathway of <b>1</b> was proposed. Notably, <b>18</b> could exert the antihepatoma effect by targeting MAPKAPK2, thereby suppressing its kinase activity and subsequent phosphorylation of HSP27 <i>in vitro</i> and <i>in vivo</i>.
Authors
- Shifang Li (ORCID: https://orcid.org/0000-0003-4614-1768)
- Xiao‐Xiao Huang (ORCID: https://orcid.org/0000-0003-0099-1118)
- Bin Lin (ORCID: https://orcid.org/0000-0003-2369-4765)
- Shao‐Jiang Song (ORCID: https://orcid.org/0000-0002-9074-2467)
- Guo‐Dong Yao (ORCID: https://orcid.org/0000-0002-1367-4886)
- Tian‐Ming Lv
- Zi‐Lin Hou
- Jian-Huan Jia
- Jiaqi Niu (ORCID: https://orcid.org/0000-0002-1121-8457)
- Yuyang Liu (ORCID: https://orcid.org/0000-0002-9164-8130)
- Yuan‐Qing Li (ORCID: https://orcid.org/0000-0002-0478-0177)
Institutions
- Shenyang Pharmaceutical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c02733
- Citations
- 1
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences