Optimization of Formula, Stability Testing, and Antioxidant Activity of Clay Masks as Skin Moisturizers

Clay masks are cosmetic formulations designed to adhere closely to the skin, effectively lifting contaminants, cleansing the face, and absorbing impurities. We made a clay mask containing active ingredients such as niacinamide, alpha arbutin, ceramide, and hyaluronic acid. A careful selection of ingredients is essential for ensuring safety and mitigating potential dermatological issues. This study aimed to evaluate the physical characteristics, stability, primary irritation potential, and moisturizing efficacy of this clay mask formulation. Kaolin and bentonite are the primary base materials. The research included formulation optimization and physical stability testing using a cycling test, where each cycle was conducted over a 24-hour period for a total of six cycles. Evaluations were performed on organoleptic properties, homogeneity, pH, spreadability, viscosity, and drying time. Subsequently, data were analyzed using paired sample T-tests. Antioxidant activity was assessed using the ABTS method to determine IC50 values. Both preclinical and clinical irritation tests were performed, and the clinical efficacy of the moisturizer was evaluated in 30 participants. The optimal formula consisted of 0.8% kaolin and 0.2% bentonite, and all the evaluation parameters met the required standards. Stability testing and percentage inhibition measurements revealed no significant differences during storage (p>0.05). The formulation demonstrated strong antioxidant activity (IC50<50) and showed no irritation in preclinical or clinical irritation tests. The efficacy results indicated that the developed clay mask formulation has significant potential as a safe and effective skin moisturizer.

Publication Details

Journal
Pharmaceutical Sciences and Research
Published
2025-07-20
DOI
https://doi.org/10.7454/psr.v12i1.1410
Citations
1
Primary Topic
Dyeing and Modifying Textile Fibers
Type
article
Field-Weighted Citation Impact
1.01
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article

Optimization of Formula, Stability Testing, and Antioxidant Activity of Clay Masks as Skin Moisturizers

1 citations
Pharmaceutical Sciences and Research
Dyeing and Modifying Textile Fibers
1.01
article

Optimization of Formula, Stability Testing, and Antioxidant Activity of Clay Masks as Skin Moisturizers

article en
1 citations

Abstract

Clay masks are cosmetic formulations designed to adhere closely to the skin, effectively lifting contaminants, cleansing the face, and absorbing impurities. We made a clay mask containing active ingredients such as niacinamide, alpha arbutin, ceramide, and hyaluronic acid. A careful selection of ingredients is essential for ensuring safety and mitigating potential dermatological issues. This study aimed to evaluate the physical characteristics, stability, primary irritation potential, and moisturizing efficacy of this clay mask formulation. Kaolin and bentonite are the primary base materials. The research included formulation optimization and physical stability testing using a cycling test, where each cycle was conducted over a 24-hour period for a total of six cycles. Evaluations were performed on organoleptic properties, homogeneity, pH, spreadability, viscosity, and drying time. Subsequently, data were analyzed using paired sample T-tests. Antioxidant activity was assessed using the ABTS method to determine IC50 values. Both preclinical and clinical irritation tests were performed, and the clinical efficacy of the moisturizer was evaluated in 30 participants. The optimal formula consisted of 0.8% kaolin and 0.2% bentonite, and all the evaluation parameters met the required standards. Stability testing and percentage inhibition measurements revealed no significant differences during storage (p>0.05). The formulation demonstrated strong antioxidant activity (IC50<50) and showed no irritation in preclinical or clinical irritation tests. The efficacy results indicated that the developed clay mask formulation has significant potential as a safe and effective skin moisturizer.

Pharmaceutical Sciences and ResearchVol. 12(1)
Openalex Percentile: Top 22%
Dyeing and Modifying Textile Fibers
1.01
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Optimization of Formula, Stability Testing, and Antioxidant Activity of Clay Masks as Skin Moisturizers · Pharmaceutical Sciences and Research (2025) | TGRS Research Map | TGRS