Investigating the Influence of Conventional vs. Ultra-High Dose Rate Proton Irradiation Under Normoxic or Hypoxic Conditions on Multiple Developmental Endpoints in Zebrafish Embryos
A radioprotective effect at a UHDR is observed both for normoxic (pericardial edema) and hypoxic (head and eye size) conditions. These results suggest that while the UHDR may preserve a potential to reduce radiation-induced damage, its protective effects are endpoint-dependent; the role of oxygenation might also be dependent on the tissue involved.
Authors
- Emanuele Scifoni (ORCID: https://orcid.org/0000-0003-1851-5152)
- Enrico Verroi (ORCID: https://orcid.org/0000-0003-0957-4505)
- Stefano Lorentini (ORCID: https://orcid.org/0000-0003-3202-2581)
- Francesco Tommasino (ORCID: https://orcid.org/0000-0002-8684-9261)
- Gaia Pucci
- Giorgio Ivan Russo (ORCID: https://orcid.org/0000-0003-4687-7353)
- Alessia Faggian (ORCID: https://orcid.org/0000-0002-3799-9722)
- Marco Calvaruso (ORCID: https://orcid.org/0000-0003-2387-8273)
- Marina Mione (ORCID: https://orcid.org/0000-0002-9040-3705)
- Alessandra Bisio (ORCID: https://orcid.org/0000-0002-3326-1923)
- Giusi Irma Forte (ORCID: https://orcid.org/0000-0003-0161-9828)
- Alberto Fasolini
- Sara Citter
Institutions
- University of Trento (IT)
- Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics And Applications (IT)
- Institute of Molecular Bioimaging and Physiology (IT)
- Provincia Autonoma di Trento (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-03
- DOI
- https://doi.org/10.3390/cancers17152564
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione Bruno Kessler