Asymmetric Nickel-Catalyzed Denitrogenative Transannulation to Construct Axially Chiral C–N Atropisomers
Here, we report an enantioselective nickel-catalyzed transannulation reaction through a denitrogenative strategy for the synthesis of new atropisomers under mild conditions. A series of axially chiral atropisomers bearing a chiral C-N bond were achieved with excellent enantioselectivities and regioselectivities. Moreover, a broad range of alkynes and 1,2,3-benzotriazinones were well tolerated by this method. The possible mechanism further reveals the role of nickel and the enantioselectivity control.
Authors
- Yanjian Wan (ORCID: https://orcid.org/0000-0002-5584-2788)
- Yafei Guo (ORCID: https://orcid.org/0000-0001-8720-3887)
- Yu Chen (ORCID: https://orcid.org/0000-0002-7572-1000)
- Wenxing Liu (ORCID: https://orcid.org/0009-0003-7718-3474)
- Jiuling Li (ORCID: https://orcid.org/0000-0002-8619-244X)
- Liangrui Xiao
Institutions
- Minzu University of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c02872
- Citations
- 2
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Yunnan Provincial Department of Education