Asymmetric (4 + 2) Cyclization of γ-Substituted Propargyl Carboxylates with <i>o</i>-Quinone Methides Catalyzed by Chiral Tertiary Phosphine
An enantioselective (4 + 2) cycloaddition reaction of γ-aryl-substituted alkynyl carboxylates with <i>ortho</i>-quinone methides (<i>o</i>-QMs) was developed for the first time in the catalysis of (<i>R</i>,<i>R</i>)-DIPAMP. A series of chiral 4H-chromenes derivatives were available in good yields (62%-89% yield) and excellent enantioselectivities (up to 96% enantiomeric excess). Those obtained products could be further transformed to other derivatives.
Authors
- Yungui Peng (ORCID: https://orcid.org/0000-0002-5815-1261)
- Rui She
- Guihua Chen (ORCID: https://orcid.org/0000-0002-2145-2765)
- Chaowei Bi (ORCID: https://orcid.org/0000-0003-4385-6397)
- Yuxing Fan
- Hongyu Liu (ORCID: https://orcid.org/0000-0003-0359-1283)
Institutions
- Southwest University (CN)
- Chongqing Municipal Government (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c02279
- Citations
- 2
- Primary Topic
- Synthesis of Indole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Fundamental Research Funds for the Central Universities