Canadian 2021 H-type Bovine Spongiform Encephalopathy case associated with a novel E211K polymorphism in prion protein gene
Bovine Spongiform Encephalopathy (BSE) is a fatal neurodegenerative disease in cattle which can be either classical BSE (C-BSE) or atypical BSE (including H-BSE and L-BSE). Here, we report the results of our analyses of an H-BSE case found in Canada in 2021, indicating restriction of the pathological agent (PrP<sup>Sc</sup>) mainly to the central nervous system with no or occasional weak involvement of peripheral tissues. Importantly, a non-synonymous mutation at codon 211 of the <i>PRNP</i> gene was detected and confirmed to be present as a germline mutation. This is the first case of BSE in Canada with a predisposing E211K mutation.
Authors
- Sandor Dudas
- Kristina Santiago-Mateo
- Yuanmu Fang
- Sarah Bogart
- Jianmin Yang (ORCID: https://orcid.org/0000-0002-6572-1541)
- Waqas Tahir (ORCID: https://orcid.org/0000-0003-3030-5625)
- Renee Anderson (ORCID: https://orcid.org/0000-0002-9800-7459)
- Roberta Quaghebeur
Institutions
- University of Lethbridge (CA)
- Canadian Food Inspection Agency (CA)
- University of Calgary (CA)
- Canadian Science Centre for Human and Animal Health (CA)
Publication Details
- Journal
- Prion
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1080/19336896.2025.2511933
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00