Gut microbiota contributes to the maintenance of sublingually induced regulatory T cells and tolerance in mice
Functional SLIT-induced Treg cells were maintained in mesenteric LNs in a gut microbiota-dependent manner. Thus, this study revealed a previously unrecognized role of the gut microbiota in SLIT and provided a rationale for targeting the gut environment to improve the efficacy and prolong the maintenance of SLIT.
Authors
- Yukinori Tanaka (ORCID: https://orcid.org/0000-0001-6170-2960)
- Shinji Fukuda (ORCID: https://orcid.org/0000-0003-0771-1158)
- Masahiro Iikubo (ORCID: https://orcid.org/0000-0001-9255-2141)
- Masato Nakano
- Saka Winias
- Shunji Sugawara
- Akiyoshi Hirayama (ORCID: https://orcid.org/0000-0002-0440-6820)
- Kanan Bando
- Takaaki Abe (ORCID: https://orcid.org/0000-0003-3170-4660)
- Kentaro Mizuta (ORCID: https://orcid.org/0000-0001-8963-9844)
- Mitsuko Komatsu
- Masahiro Saito (ORCID: https://orcid.org/0000-0001-7051-1517)
- Boonnapa Temtanapat
Institutions
- Tohoku University (JP)
- Keio University (JP)
- Universitas Airlangga (ID)
Publication Details
- Journal
- Allergology International
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.alit.2025.06.003
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Yakult Bio-Science Foundation
- Japan Society for the Promotion of Science