Evaluation of Tyrosine Kinase-2 (TYK2) signaling pathway gene expression and the presence of the single-nucleotide polymorphism rs12720356 in the peripheral blood of patients with severe psoriasis and loss of systemic treatment response
The present study suggests an association between multiple TYK2 pathway markers and loss of systemic treatment response.
Authors
- Luciana Pereira Freire Martins
- Bruna Côrtes Rodrigues (ORCID: https://orcid.org/0000-0003-1567-0288)
- Carla Nunes de Araújo (ORCID: https://orcid.org/0000-0002-1788-9745)
- Ciro Martins Gomes (ORCID: https://orcid.org/0000-0002-3069-6884)
- Melissa Soares Medeiros (ORCID: https://orcid.org/0000-0002-5881-1485)
- Patrícia Shu Kurizky (ORCID: https://orcid.org/0000-0002-5759-2727)
- Renata Velôzo Timbó (ORCID: https://orcid.org/0000-0003-1989-7412)
- Otávio de Tolêdo Nóbrega (ORCID: https://orcid.org/0000-0003-1775-7176)
- Nélio Santos (ORCID: https://orcid.org/0009-0007-1797-4388)
- Andréa Monteiro de Araújo (ORCID: https://orcid.org/0000-0002-7347-8246)
- Lícia Maria Henrique da Mota (ORCID: https://orcid.org/0000-0002-8182-5121)
- Agenor De Castro Moreira Dos Santos
- Paola Borges Eckstein Canabrava (ORCID: https://orcid.org/0000-0002-1012-7529)
- Roll Stanley Beauge
- Samir de Figueiredo Azouz
Institutions
- Universidade de Brasília (BR)
- Universidade Federal da Paraíba (BR)
Publication Details
- Journal
- Anais Brasileiros de Dermatologia
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1016/j.abd.2025.501165
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Apoio à Pesquisa do Distrito Federal