The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort
Inflammatory mechanisms represented by GFAP were linked to tau pathology and WMH and also moderated the association between WMH on cognitive performance.
Authors
- Jacklyn Leonardo (ORCID: https://orcid.org/0000-0003-0878-8149)
- Nagaendran Kandiah (ORCID: https://orcid.org/0000-0001-9244-4298)
- Xueling Sim (ORCID: https://orcid.org/0000-0002-1233-7642)
- Ashwati Vipin (ORCID: https://orcid.org/0000-0002-3575-7287)
- Bocheng Qiu
- Yi Jin Leow (ORCID: https://orcid.org/0000-0003-3661-4816)
- Faith Phemie Hui En Lee
- Gurveen Kaur Sandhu
- Gaurav Bhalla (ORCID: https://orcid.org/0000-0003-0337-3809)
- Fatin Zahra Zailan
- Smriti Ghildiyal (ORCID: https://orcid.org/0009-0007-7765-3551)
- Pricilia Tanoto (ORCID: https://orcid.org/0009-0002-5456-690X)
- Reza Salim
- Shan Yao Liew
Institutions
- Nanyang Technological University (SG)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100300
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Ministry of Education - Singapore
- Nanyang Technological University
- National Medical Research Council
- Lee Kong Chian School of Medicine, Nanyang Technological University