Interpretable Deep Learning Models for Arrhythmia Classification Based on ECG Signals Using PTB-X Dataset

<b>Background/Objectives:</b> Automatic classification of ECG signal arrhythmias plays a vital role in early cardiovascular diagnostics by enabling prompt detection of life-threatening conditions. Manual ECG interpretation is labor-intensive and susceptible to errors, highlighting the demand for automated, scalable approaches. Deep learning (DL) methods are effective in ECG analysis due to their ability to learn complex patterns from raw signals. <b>Methods</b>: This study introduces two models: a custom convolutional neural network (CNN) with a dual-branch architecture for processing ECG signals and demographic data (e.g., age, gender), and a modified VGG16 model adapted for multi-branch input. Using the PTB-XL dataset, a widely adopted large-scale ECG database with over 20,000 recordings, the models were evaluated on binary, multiclass, and subclass classification tasks across 2, 5, 10, and 15 disease categories. Advanced preprocessing techniques, combined with demographic features, significantly enhanced performance. <b>Results</b>: The CNN model achieved up to 97.78% accuracy in binary classification and 79.7% in multiclass tasks, outperforming the VGG16 model (97.38% and 76.53%, respectively) and state-of-the-art benchmarks like CNN-LSTM and CNN entropy features. This study also emphasizes interpretability, providing lead-specific insights into ECG contributions to promote clinical transparency. <b>Conclusions</b>: These results confirm the models' potential for accurate, explainable arrhythmia detection and their applicability in real-world healthcare diagnostics.