The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Glandular Lesions of the Urinary Bladder

The Dublin ISUP Consensus Conference covered the proceedings on the best practice recommendations on nonurachal glandular lesions of the urinary bladder, bladder diverticular cancers, and molecular features of bladder and urachal glandular lesions. The conference proceedings on urachal neoplasms (except for their molecular features) are published elsewhere. The rationale for convening this conference was the lack of structured and consented pathologic recommendations in these rare lesions. Consensus by participants was reached on the following statements: (1) intestinal metaplasia with dysplasia is considered to be a precursor to primary bladder adenocarcinoma; (2) dysplasia arising from cystitis glandularis should be reported in terms of focality (focal or nonfocal) and grade (low or high); (3) the term "adenocarcinoma" should only be used for carcinomas showing pure (nonurothelial) morphology and should not be used interchangeably in urothelial carcinoma with "glandular differentiation" because of the pathobiological differences and management implications; (4) the different histologic subtypes of bladder adenocarcinoma should be specified in the report; (5) immunohistochemistry has an ancillary role in the work up of bladder adenocarcinoma versus gastrointestinal or Müllerian-type adenocarcinomas; (6) lymphovascular invasion should be included as a parameter when reporting bladder adenocarcinoma; (7) representative or targeted sampling will be sufficient for bladder diverticulum resection specimens; and (8) molecular analysis in genomic profiling should be performed only in advanced or metastatic bladder and urachal adenocarcinomas for targetable therapy. This report on glandular (nonurachal) lesions of the bladder from the Dublin ISUP consensus conference will serve as a best practice recommendation and as a guide for future research on these relatively rare lesions.

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Journal
Advances in Anatomic Pathology
Published
2025-08-04
DOI
https://doi.org/10.1097/pap.0000000000000510
Citations
4
Primary Topic
Urinary and Genital Oncology Studies
Type
article
Field-Weighted Citation Impact
8.03
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article

The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Glandular Lesions of the Urinary Bladder

Jonathan Aning, Fiona Maclean, Charles Chuanhai Guo, Eiji Kikuchi et al.
4 citations
Advances in Anatomic Pathology
Urinary and Genital Oncology Studies
8.03
article

The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Glandular Lesions of the Urinary Bladder

Jonathan Aning, Fiona Maclean, Charles Chuanhai Guo, Eiji Kikuchi, Anuradha Gopalan, Henning Reis, Glen Kristiansen, Valeria Panebianco, Hikmat A Al‐Ahmadie, Kosuke Miyai, Toyonori Tsuzuki, Sara E. Wobker, Tibor Szarvas, Gladell P. Paner, Manju Aron, Carole A. Harris, Arlene O. Siefker‐Radtke, Gopa Iyer, George J. Netto, Steven C. Smith, Nadine Therese Gaisa, Richard Bambury, Christian Gulmann, Daniel Abensur Athanazio, Liang Cheng, Rafael E. Jiménez, Priti Lal, Mahul B. Amin, Antonio López-Beltrán, Chin-Chen Pan, Masahiro Jinzaki, Isabela W. Cunha, Bas W. van Rhijn
article en
4 citations

Abstract

The Dublin ISUP Consensus Conference covered the proceedings on the best practice recommendations on nonurachal glandular lesions of the urinary bladder, bladder diverticular cancers, and molecular features of bladder and urachal glandular lesions. The conference proceedings on urachal neoplasms (except for their molecular features) are published elsewhere. The rationale for convening this conference was the lack of structured and consented pathologic recommendations in these rare lesions. Consensus by participants was reached on the following statements: (1) intestinal metaplasia with dysplasia is considered to be a precursor to primary bladder adenocarcinoma; (2) dysplasia arising from cystitis glandularis should be reported in terms of focality (focal or nonfocal) and grade (low or high); (3) the term "adenocarcinoma" should only be used for carcinomas showing pure (nonurothelial) morphology and should not be used interchangeably in urothelial carcinoma with "glandular differentiation" because of the pathobiological differences and management implications; (4) the different histologic subtypes of bladder adenocarcinoma should be specified in the report; (5) immunohistochemistry has an ancillary role in the work up of bladder adenocarcinoma versus gastrointestinal or Müllerian-type adenocarcinomas; (6) lymphovascular invasion should be included as a parameter when reporting bladder adenocarcinoma; (7) representative or targeted sampling will be sufficient for bladder diverticulum resection specimens; and (8) molecular analysis in genomic profiling should be performed only in advanced or metastatic bladder and urachal adenocarcinomas for targetable therapy. This report on glandular (nonurachal) lesions of the bladder from the Dublin ISUP consensus conference will serve as a best practice recommendation and as a guide for future research on these relatively rare lesions.

Advances in Anatomic PathologyVol. 33(1)
Semmelweis University (HU), University of North Carolina at Chapel Hill (US), Goethe University Frankfurt (DE), University of Southern California (US), North Bristol NHS Trust (GB), Memorial Sloan Kettering Cancer Center (US), The University of Texas MD Anderson Cancer Center (US), University of Tennessee Health Science Center (US), St. Marianna University School of Medicine (JP), Aichi Medical University (JP), Keio University (JP), Cornell University (US), Brown University (US), University Hospital Bonn (DE), Policlinico Umberto I (IT), Southmead Hospital (GB), Beaumont Hospital (IE), Cork University Hospital (IE), Taipei Veterans General Hospital (TW), UNSW Sydney (AU), University of Chicago (US), National Defense Medical College Hospital (JP), Complexo Hospitalar Universitário Professor Edgard Santos (BR), D’Or Institute for Research and Education (BR), Douglass Hanly Moir Pathology (AU), Essen University Hospital (DE), St George Hospital (AU), Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL), Mayo Clinic in Arizona (US), University Hospital Frankfurt (DE), Precision Research (United States) (US), St. George Hospital (IN), University Hospital Ulm (DE), Caritas-Krankenhaus St. Josef (DE), West German Heart and Vascular Center Essen (DE), Children's Hospital of Richmond at VCU (US), University of Córdoba (ES), University of Regensburg (DE), University of Duisburg-Essen (DE), University of Pennsylvania (US), RWTH Aachen University (DE), Macquarie University (AU)
Good health and well-being
Openalex Percentile: Top 2%
Urinary and Genital Oncology Studies
8.03
DOISourceOpenAlex
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