Retinal metastasis from lung adenocarcinoma: a case report

Retinal metastasis is an exceedingly rare manifestation of systemic cancer, accounting for less than 1% of ocular metastases. Lung adenocarcinoma is among the primary tumors that can metastasize to the retina, though such cases are seldom reported. We present a 70-year-old male with a history of lung adenocarcinoma who presented with a decline in vision in his left eye. Fundus examination revealed a large yellow-white lesion with hemorrhage in the macula and temporal retina. Multimodal imaging, including optical coherence tomography (OCT) and fluorescein angiography (FA), confirmed the diagnosis of retinal metastasis. This case underscores the importance of considering retinal metastasis in cancer patients with visual disturbances. Early diagnosis through comprehensive ophthalmic evaluation is crucial to avoid misdiagnosis.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-08-04
DOI
https://doi.org/10.3389/fonc.2025.1616331
Primary Topic
Ocular Oncology and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Retinal metastasis from lung adenocarcinoma: a case report

Jun Xiao, Bo Yang, Danfeng Li, Lifu Luo
Frontiers in Oncology
Ocular Oncology and Treatments
article

Retinal metastasis from lung adenocarcinoma: a case report

Jun Xiao, Bo Yang, Danfeng Li, Lifu Luo
article en

Abstract

Retinal metastasis is an exceedingly rare manifestation of systemic cancer, accounting for less than 1% of ocular metastases. Lung adenocarcinoma is among the primary tumors that can metastasize to the retina, though such cases are seldom reported. We present a 70-year-old male with a history of lung adenocarcinoma who presented with a decline in vision in his left eye. Fundus examination revealed a large yellow-white lesion with hemorrhage in the macula and temporal retina. Multimodal imaging, including optical coherence tomography (OCT) and fluorescein angiography (FA), confirmed the diagnosis of retinal metastasis. This case underscores the importance of considering retinal metastasis in cancer patients with visual disturbances. Early diagnosis through comprehensive ophthalmic evaluation is crucial to avoid misdiagnosis.

Frontiers in OncologyVol. 15
Second Affiliated Hospital of Jilin University (CN)
People's Government of Jilin Province, Department of Science and Technology of Jilin Province
Good health and well-being
Openalex Percentile: Top 70%
Ocular Oncology and Treatments
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Retinal metastasis from lung adenocarcinoma: a case report — Jun Xiao, Bo Yang, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS