Proteomics and the Risk of Incident Embolic and Thrombotic Stroke
We identified plasma proteins associated with risk of EIS versus TIS reflecting distinct stroke mechanisms: cardiac dysfunction protein in EIS (eg, NPPB) and inflammation dysregulation in TIS (eg, interleukins). ANN NEUROL 2025;98:1125-1135.
Authors
- James Russell Pike (ORCID: https://orcid.org/0000-0002-6858-620X)
- Rebecca F. Gottesman (ORCID: https://orcid.org/0000-0002-9504-1256)
- Ziqiao Wang (ORCID: https://orcid.org/0000-0003-3383-8670)
- James S. Floyd (ORCID: https://orcid.org/0000-0002-0365-9041)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Michelle C. Johansen (ORCID: https://orcid.org/0000-0003-0393-3589)
- Lin Y. Chen (ORCID: https://orcid.org/0000-0002-0700-814X)
- Wendy Wang (ORCID: https://orcid.org/0000-0001-6025-0173)
- Myriam Fornage (ORCID: https://orcid.org/0000-0003-0677-8158)
- Jinyu Chen (ORCID: https://orcid.org/0009-0002-7444-2963)
- Rizwan Kalani (ORCID: https://orcid.org/0000-0003-0700-1439)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Minnesota (US)
- Johns Hopkins University (US)
- University of Washington (US)
- Johns Hopkins Medicine (US)
- National Institute of Neurological Disorders and Stroke (US)
- MNGI Digestive Health (US)
- National Institute on Aging (US)
- Institute of Aging (CA)
- The University of Texas Health Science Center (US)
- Optimal Solutions (United States) (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1002/ana.70011
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- National Institute of Neurological Disorders and Stroke