Trends in Term-Equivalent Age Brain Volumes in Infants Born Across the Gestational Age Spectrum
Our results suggest that GA has an effect on TEA brain volumes that is independent of brain lesions, with lower GA being associated with smaller brain tissue volumes and significantly larger cerebrospinal fluid volume. Preterm birth and related exposures may thus affect early brain growth and contribute to neurodevelopmental challenges encountered by preterm-born children.
Authors
- Martijn F. Boomsma (ORCID: https://orcid.org/0000-0002-7878-0970)
- Elsa Fiedrich (ORCID: https://orcid.org/0000-0002-9598-3438)
- Amy Metcalfe (ORCID: https://orcid.org/0000-0003-4449-9256)
- Lara M. Leijser (ORCID: https://orcid.org/0000-0001-5458-3721)
- Alexander Leemans (ORCID: https://orcid.org/0000-0002-9306-6126)
- Ingrid M. Nijholt (ORCID: https://orcid.org/0000-0003-4820-7505)
- Anouk S. Verschuur (ORCID: https://orcid.org/0000-0001-8737-7078)
- Amy Bergeron (ORCID: https://orcid.org/0000-0002-4224-0307)
- Gerda van Wezel‐Meijler (ORCID: https://orcid.org/0000-0002-4380-7758)
- Chantal M. W. Tax (ORCID: https://orcid.org/0000-0002-7480-8817)
- Donna M. Slater (ORCID: https://orcid.org/0000-0003-2811-3632)
- Selma Low
- Jannice Skiffington (ORCID: https://orcid.org/0000-0003-1857-390X)
Institutions
- University of Calgary (CA)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- Isala (NL)
- Cardiff University (GB)
Publication Details
- Journal
- Children
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3390/children12081026
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Koninklijke Nederlandse Akademie van Wetenschappen
- Alberta Children's Hospital Foundation