CLINICAL PROFILE AND OUTCOMES OF PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder affecting reproductive-age women globally, with prevalence ranging 5-26%. Despite its significance, comprehensive clinical profiling and outcome assessment remain limited in South Asian populations. This study aimed to evaluate clinical characteristics and treatment outcomes in women with PCOS at a tertiary care center. Methods: A prospective observational study was conducted at Gynecology, Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh from June 2015 to July 2016. One hundred eighty women aged 18-40 years diagnosed with PCOS according to Rotterdam criteria were enrolled using consecutive sampling. Comprehensive clinical, anthropometric, biochemical, and hormonal assessments were performed. Treatment outcomes were evaluated at 6-month follow-up. Statistical analysis was performed using SPSS version 20.0. Results: Mean age was 24.6±4.8 years with 70% participants having BMI≥25 kg/m². Menstrual irregularities affected 90% participants, hirsutism 75%, and polycystic ovarian morphology 85%. Insulin resistance (HOMA-IR>2.5) was present in 60% participants, with 80% showing elevated testosterone levels. Family history of diabetes and PCOS was observed in 40% and 30% respectively. Treatment interventions demonstrated significant improvements: lifestyle modifications reduced BMI (26.8±5.2 to 25.4±4.8 kg/m², p<0.001), metformin improved insulin sensitivity, oral contraceptives reduced hyperandrogenic symptoms, and clomiphene achieved 72.2% ovulation rate with 33.3% pregnancy rate. Conclusion: PCOS presents as a complex metabolic-reproductive syndrome with high prevalence of obesity, insulin resistance, and metabolic dysfunction in South Asian women. Comprehensive, individualized treatment approaches significantly improve clinical outcomes and quality of life, emphasizing the importance of multidisciplinary management strategies.