Targeting MMP-7 in idiopathic pulmonary fibrosis: An integrative in vivo and in silico evaluation of the therapeutic potential of Tylophora indica
T. indica extract demonstrated significant antifibrotic activity by downregulating MMP-7 expression and improving lung histopathology in the IPF mouse model. The identified phytochemicals show strong potential as natural MMP-7 inhibitors, suggesting T. indica as a prospective therapeutic agent for IPF. Additional clinical studies are required to validate these results.
Authors
- Md. Asaduzzaman Sikder (ORCID: https://orcid.org/0000-0003-1297-5019)
- Marina Khatun (ORCID: https://orcid.org/0000-0003-2253-5199)
- Dibyendu Halder
- Md Atiquzzaman (ORCID: https://orcid.org/0000-0002-2590-6752)
- Umme Mim Sad Jahan
- Md Khairul Islam (ORCID: https://orcid.org/0000-0002-9125-9573)
- Md. Sabbir Mostafa Khan
- A. H. M. SAIDUL HASAN
- T. K. Sue
- Mohammad Ali
- Rabeya Bashree Keya
Institutions
- Mawlana Bhashani Science and Technology University (BD)
Publication Details
- Journal
- Computers in Biology and Medicine
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1016/j.compbiomed.2025.110867
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52