Involvement of the brain orexin system in a familial form of anorexia nervosa
Anorexia nervosa (AN) is a debilitating eating disorder. To date, only a few genes have been identified as predisposing to AN. The <i>HCRTR1</i> gene is known to be involved in the regulation of feeding and physical activity. The identification of a rare loss-of-function variant in <i>HCRTR1</i> strongly suggests that the orexin pathway may be involved in the predisposition to anorexia nervosa.
Authors
- Nicolás Ramoz (ORCID: https://orcid.org/0000-0002-8070-9938)
- Philibert Duriez (ORCID: https://orcid.org/0000-0001-7321-6820)
- Philip A. P. M. Gorwood (ORCID: https://orcid.org/0000-0003-1845-3676)
- Thierry Bienvenu (ORCID: https://orcid.org/0000-0002-5953-2728)
- Bertrand Diebold
- Natacha Gaitch
- Nicolas Lebrun (ORCID: https://orcid.org/0000-0002-0043-3821)
- Camille Verebi (ORCID: https://orcid.org/0000-0002-0524-4827)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Sainte-Anne (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- FHU Neurovasc (FR)
Publication Details
- Journal
- The World Journal of Biological Psychiatry
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1080/15622975.2025.2537947
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondation Maladies Rares