Evaluation of the Antidiabetic, Hypolipidemic and Hepatoprotective Effect of Allium sativum in Diabetic Rats

Background: Diabetes is a metabolic disorder and is rapidly raising worldwide. It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia induced reactive oxygen species (ROS) production and oxidative stress are correlated with the pathogenesis and progression of diabetes. To counteract the harmful effects of ROS, antioxidants of the body neutralise it and maintain bodily homeostasis. Allium sativum (garlic) is a medicinal plant which is used in Indian traditional medicine to treat or prevent many diseases like cancer, hepatitis, and diabetes. Aim: The main aim of this study was to investigate the effect of garlic extract on oxidative stress and dyslipidemia in diabetic rats. Methods: In this study, 30 male Wistar rats weighing 200± 20gr are randomly divided to five groups of 6 each including healthy normal control (group I), garlic treatment (group II), diabetic control (group II), diabetic animals treated with garlic positive control (group III) and diabetic animals treated vitamin C. Diabetes mellitus was experimentally induced by injection of STZ. Findings: In our study, we observed significant increase in Blood glucose, Malondialdehyde (MDA), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) and serum markers in diabetic rats. However, with garlic treatment all these lipid metabolic profiles and serum markers are came back to near to normalcy. Conclusion: Our study reported that garlic possess hepatoprotective antioxidant and antilipidemic effect in diabetic rats.So consumption of garlic helpful to diabetic patients.