LLM as Entity Disambiguator for Biomedical Entity-Linking

Entity linking involves normalizing a mention in medical text to a unique identifier in a knowledge base, such as UMLS or MeSH.Most entity linkers follow a two-stage process: first, a candidate generation step selects highquality candidates, and then a named entity disambiguation phase determines the best candidate for final linking.This study demonstrates that leveraging a large language model (LLM) as an entity disambiguator significantly enhances entity linking models' accuracy and recall.Specifically, the LLM disambiguator achieves remarkable improvements when applied to alias-matching entity linking methods.Without any fine-tuning, our approach establishes a new state-of-the-art (SOTA), surpassing previous methods on multiple prevalent biomedical datasets by up to 16 points in accuracy.

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Publication Details

Published
2025-01-01
DOI
https://doi.org/10.18653/v1/2025.acl-short.25
Primary Topic
Biomedical Text Mining and Ontologies
Type
article
Field-Weighted Citation Impact
0.00

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article

LLM as Entity Disambiguator for Biomedical Entity-Linking

Christophe Ye, Cassie S. Mitchell
Biomedical Text Mining and Ontologies
article

LLM as Entity Disambiguator for Biomedical Entity-Linking

Christophe Ye, Cassie S. Mitchell
article en

Abstract

Entity linking involves normalizing a mention in medical text to a unique identifier in a knowledge base, such as UMLS or MeSH.Most entity linkers follow a two-stage process: first, a candidate generation step selects highquality candidates, and then a named entity disambiguation phase determines the best candidate for final linking.This study demonstrates that leveraging a large language model (LLM) as an entity disambiguator significantly enhances entity linking models' accuracy and recall.Specifically, the LLM disambiguator achieves remarkable improvements when applied to alias-matching entity linking methods.Without any fine-tuning, our approach establishes a new state-of-the-art (SOTA), surpassing previous methods on multiple prevalent biomedical datasets by up to 16 points in accuracy.

Georgia Institute of Technology (US)
National Science Foundation
Openalex Percentile: Top 83%
Biomedical Text Mining and Ontologies
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