Enhancing Antimicrobial Drug Resistance Classification by Integrating Sequence-Based and Text-Based Representations

Antibiotic resistance identification is essential for public health, medical treatment, and drug development.Traditional sequence-based models struggle with accurate resistance prediction due to the lack of biological context.To address this, we propose an NLP-based model that integrates genetic sequences with structured textual annotations, including gene family classifications and resistance mechanisms.Our approach leverages pretrained language models for both genetic sequences and biomedical text, aligning biological metadata with sequence-based embeddings.We construct a novel dataset based on the Antibiotic Resistance Ontology (ARO), consolidating gene sequences with resistancerelated textual information.Experiments show that incorporating domain knowledge significantly improves classification accuracy over sequence-only models, reducing reliance on exhaustive laboratory testing.By integrating genetic sequence processing with biomedical text understanding, our approach provides a scalable and interpretable solution for antibiotic resistance prediction.