UIC at ArchEHR-QA 2025: Tri-Step Pipeline for Reliable Grounded Medical Question Answering

Automated response generation from electronic health records (EHRs) holds potential to reduce clinician workload, but it introduces important challenges related to factual accuracy and reliable grounding in clinical evidence.We present a structured three-step pipeline that uses large language models (LLMs) for evidence classification, guided response generation, and iterative quality control.To enable rigorous evaluation, our framework combines traditional reference-based metrics with a claim-level "LLM-as-a-Judge" methodology.On the ArchEHR-QA benchmark, our system achieves 82.0 percent claim-level evidence faithfulness and 51.6 percent citation-level factuality, demonstrating strong performance in generating clinically grounded responses.These findings highlight the utility of structured LLM pipelines in healthcare applications, while also underscoring the importance of transparent evaluation and continued refinement.All code, prompt templates, and evaluation tools are publicly available.

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Publication Details

Published
2025-01-01
DOI
https://doi.org/10.18653/v1/2025.bionlp-share.14
Primary Topic
Topic Modeling
Type
article
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article

UIC at ArchEHR-QA 2025: Tri-Step Pipeline for Reliable Grounded Medical Question Answering

Karl M. Kochendorfer, Anil Kumar Gautam, Mohammad Arvan, Mohan Zalake
Topic Modeling
article

UIC at ArchEHR-QA 2025: Tri-Step Pipeline for Reliable Grounded Medical Question Answering

Karl M. Kochendorfer, Anil Kumar Gautam, Mohammad Arvan, Mohan Zalake
article en

Abstract

Automated response generation from electronic health records (EHRs) holds potential to reduce clinician workload, but it introduces important challenges related to factual accuracy and reliable grounding in clinical evidence.We present a structured three-step pipeline that uses large language models (LLMs) for evidence classification, guided response generation, and iterative quality control.To enable rigorous evaluation, our framework combines traditional reference-based metrics with a claim-level "LLM-as-a-Judge" methodology.On the ArchEHR-QA benchmark, our system achieves 82.0 percent claim-level evidence faithfulness and 51.6 percent citation-level factuality, demonstrating strong performance in generating clinically grounded responses.These findings highlight the utility of structured LLM pipelines in healthcare applications, while also underscoring the importance of transparent evaluation and continued refinement.All code, prompt templates, and evaluation tools are publicly available.

Openalex Percentile: Top 90%
Topic Modeling
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