Survival and pathological response in pancreatic ductal adenocarcinoma after preoperative therapy with PD-1 blockade plus chemoradiotherapy followed by surgical resection
NAT with PD-1 blockade plus chemoradiotherapy was associated with a higher CPR rate in resected PDAC. Age and tumor size decrease were predictive factors for PR. PV/SMV invasion, resectability status, and preoperative CA 19-9 levels were independent prognostic factors for survival.
Authors
- Min Tang (ORCID: https://orcid.org/0000-0001-9990-0292)
- Juan Du (ORCID: https://orcid.org/0000-0001-8190-3524)
- Shanshan Shen (ORCID: https://orcid.org/0000-0003-3249-1564)
- Aimei Li (ORCID: https://orcid.org/0000-0001-7908-9391)
- Yudong Qiu (ORCID: https://orcid.org/0000-0002-6017-9757)
- Defu Hu (ORCID: https://orcid.org/0000-0001-5275-4646)
- Liang Mao (ORCID: https://orcid.org/0000-0002-7112-9421)
- Jun Chen (ORCID: https://orcid.org/0000-0002-2362-5359)
- Jialing Li (ORCID: https://orcid.org/0000-0003-1827-9313)
- Song Zhang
- Lei Wang (ORCID: https://orcid.org/0000-0002-1827-5470)
- Qi Li (ORCID: https://orcid.org/0000-0001-8788-0992)
- Jian He (ORCID: https://orcid.org/0000-0002-5142-6357)
- Hao Cheng (ORCID: https://orcid.org/0000-0001-6621-7614)
- Huizi Sha (ORCID: https://orcid.org/0000-0001-6820-8885)
- Elyar Abaydulla
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1080/07853890.2025.2541314
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 3.14