Triple C–F bond functionalization <i>via</i> an orderly elimination–oxidation–substitution relay reaction
A comovement group strategy is presented, which enables an orderly triple C–F bond functionalization process, providing practical access to α-ketoamides from readily available reagents by using water and oxygen in air as oxygen atom sources.
Authors
- Xinfang Xu (ORCID: https://orcid.org/0000-0002-8706-5151)
- Hui Miao (ORCID: https://orcid.org/0000-0002-5446-1756)
- Xiongda Xie
- Xiao‐Song Xue (ORCID: https://orcid.org/0000-0003-4541-8702)
- Lixin Qian (ORCID: https://orcid.org/0000-0002-6532-6787)
- Yufei Zhang (ORCID: https://orcid.org/0000-0002-0586-4073)
- Kewei Chen (ORCID: https://orcid.org/0000-0002-3351-7714)
- Gang Chen (ORCID: https://orcid.org/0000-0003-4234-1359)
- Haoran Xu (ORCID: https://orcid.org/0000-0002-8415-7085)
Institutions
- Zhejiang Sci-Tech University (CN)
- Sun Yat-sen University (CN)
- Shanghai Advanced Research Institute (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Hangzhou Academy of Agricultural Sciences (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00864f
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences