Three-component reaction of isocyanates and 3-aminoacrylates: selective synthesis of <i>N</i>-2-aryl-1,2,3-triazoles and hydrazones

This study presents a novel three-component reaction of nitrogen sources, 3-aminoacrylates and isocyanates, enabling the condition-controlled selective synthesis of <i>N</i>-2-aryl 1,2,3-triazoles and polyfunctionalized hydrazones. In this transformation, (NH₄)₂Ce(NO₃)₆ and TBN, in combination with isocyanates, serve as nitrogen sources, replacing conventional hydrazine or diazo reagents. This process involves the construction of two N-N bonds, demonstrating broad substrate compatibility and excellent functional group tolerance.