Association analysis-based screening strategy for quality markers of Tengdan capsule in the treatment of hypertensive renal disease
This study presents a novel framework for Q-marker identification in traditional herbal formulations using association-based multi-omics integration. Salvianolic acid B and KLRD1 were key indicators of TDC's quality and efficacy. These findings offer new mechanistic insights into the action of TDC and support its standardized evaluation and therapeutic application in HRD management.
Authors
- Jinzhe Liu (ORCID: https://orcid.org/0000-0002-7110-0821)
- Fang Wang (ORCID: https://orcid.org/0000-0003-0871-3454)
- Ying Wang (ORCID: https://orcid.org/0000-0002-7852-386X)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3113-4015)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-2652-3988)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-3614-0799)
- Xiaoli Du
- Yu Dong (ORCID: https://orcid.org/0000-0002-5978-7202)
Institutions
- Buchang Pharma (China) (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.3389/fphar.2025.1647921
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00