Immune checkpoint changes correlate with the progression and prognosis of amyotrophic lateral sclerosis
Our research demonstrated a considerable increase in membrane-bound and soluble PD-1 in ALS patients, correlating with disease progression and worse prognosis. Furthermore, we explored 13 other immune checkpoint molecules. Collectively, these molecules may be implicated in peripheral immune mechanisms underlying ALS pathogenesis. While baseline PD-1 levels show some association with prognosis, their elevation potentially indicates an unfavorable course.
Authors
- Huapin Huang (ORCID: https://orcid.org/0000-0003-0476-756X)
- Yali Huang (ORCID: https://orcid.org/0000-0001-8263-6368)
- Feifei Lin (ORCID: https://orcid.org/0009-0008-8525-1955)
- Shanlin Ke (ORCID: https://orcid.org/0000-0003-4101-0574)
- Zhang‐Yu Zou
- Sheng Chen (ORCID: https://orcid.org/0000-0002-7934-015X)
- Jiaqi Li (ORCID: https://orcid.org/0000-0001-9038-9010)
- Jialin Chen (ORCID: https://orcid.org/0000-0002-7519-0545)
- Ying‐Qian Lu
- Chun‐Zuan Xu (ORCID: https://orcid.org/0009-0003-1186-4971)
- Changyun Liu (ORCID: https://orcid.org/0009-0006-8030-8911)
Institutions
- Fujian Medical University (CN)
- Education Department of Fujian Province (CN)
- Precision for Medicine (United States) (US)
- Union Hospital (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1080/07853890.2025.2540023
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China