Evaluation of Nutritional and Inflammatory Status Using Naples Prognostic Score Measurements in Patients with Erectile Dysfunction

Objective: To investigate the relationship between the presence and severity of erectile dysfunction (ED) and the Naples prognostic score (NPS). Materials and Methods: Data from patients who presented to two urology outpatient clinics with complaints of ED between July 2024 and January 2025 were retrospectively analyzed. Patients older than 18 years of age engaged in regular sexual activities were included. A total of 163 patients with ED meeting the inclusion criteria and 160 healthy controls without ED were evaluated. Patients’ age, weight, height, comorbidities, laboratory findings, and International Index of Erectile Function-5 scores were recorded at baseline. Results: The mean ages of the patients with ED and controls were 58.7±12.4 and 56.9±12.8 years, respectively (p=0.197). In the multivariate analysis between the ED and control groups, the neutrophil-to-lymphocyte ratio (p=0.009) and the presence of NPS 3-4 (p<0.001) were identified as independent variables. Multivariate analysis comparing mild and mild-to-moderate ED groups with moderate and severe ED groups showed that the presence of NPS 3-4 was the only independent predictor of increased ED severity (NPS group 3-4 vs. NPS group 1-2, p=0.021; NPS group 3-4 vs. NPS group 0, p=0.007). Conclusion: NPS was higher in patients with ED compared to healthy controls. In addition, NPS was significantly higher in patients with moderate and severe ED than in those with mild or mild-to-moderate ED.