Alloanti‐D in a <scp>DBT</scp> pregnant woman responsible for hemolytic disease of the fetus and newborn: Molecular study and genetic counseling

The RHD variant identified in the maternal sample was responsible for a partial D phenotype. This case highlights the limitations of routine serologic typing for the D antigen, which misidentified a partial D phenotype as D+, preventing the patient from receiving appropriate prophylactic RhIg treatment. Interestingly, the QMPSF-based strategy resulted in a simple, reliable, and effective method for a relevant allele characterization in all family members. Noteworthy, genetic counseling was provided to the proband's brother carrying the RHD*14.02 variant at the heterozygous state with an RHD*01 allele.